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神经病理性痛是一种由于躯体感觉神经系统的损伤或疾病而直接造成的疼痛。Sonic hedgehog(Shh)信号转导通路是经典的控制胚胎发育的信号转导途径。近年来发现，该信号途径不仅参与胚胎神经系统模式发育，在成熟机体的稳态调节中也发挥重要作用，因此正逐渐成为信号转导领域新的研究热点。最新文献表明，Shh通路调节神经病理性疼痛的痛觉敏化，且其可能机制与星形胶质细胞激活，炎症因子以及突触可塑性的改变相关。","Neuropathy pain is a kind of pain due to injury or disease to the body of sensory nerve system. Sonic hedgehog (Shh) signal transduction pathway is a classic control signal transduction pathways in embryonic development. And it be found that the signaling pathways involved in the development of the nervous system model in mature steady state, so is becoming a hot spot in the ifeld of new signal transduction. Novel studies have demonstrated that the Shh pathway is associated with pain sensitization in neuropathy pain. And its mechanism maybe about astrocyte activation, inlfammation factors and the change of the synaptic plasticity.