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目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)肾病患者(diabetic nephropathy,DN)血清抵抗素与C-反应蛋白(C-reactive protein,CRP)的相关性及临床意义。方法分别检测30例T2DM合并DN患者、30例T2DM无DN患者、30例正常对照者的血清抵抗素、CRP、空腹血糖(FPG)、空腹血胰岛素(FIns)水平与胰岛素抵抗指数(Homa-IR)。结果 T2DM患者组的血清抵抗素、CRP、FPG、FIns、Homa-IR值均较正常对照组为高(p<0.05),虽然T2DM合并DN组的血清抵抗素、FPG、FIns、Homa-IR值较T2DM无DN组均值有升高趋势,但差异不显著(p>0.05)。另外,T2DM合并DN组的血清CRp值较T2DM无DN组增高(p<0.05)。相关分析显示,T2DM合并DN组的血清抵抗素、CRP水平两者间及其与FPG、FIns、Homa-IR间均呈中度正相关(p<0.05)。结论抵抗素、CRP与T2DM合并DN患者的胰岛素抵抗中度相关,对两者的动态监测可从一定程度上反映出患者病情的变化。
Objective To investigate the relationship and clinical significance of serum resistin and C-reactive protein (CRP) in type 2 diabetes mellitus (T2DM) patients with nephropathy (DN). Methods Serum levels of resistin, CRP, fasting plasma glucose (FPG), fasting plasma insulin (FIns) and insulin resistance index (Homa-IR) were measured in 30 T2DM patients with DN, 30 T2DM without DN patients and 30 healthy controls. ). Results The levels of serum resistin, CRP, FPG, FIns and Homa-IR in T2DM patients were higher than those in normal controls (p <0.05). Although serum resistin, FPG, FIns and Homa-IR in T2DM with DN were higher Compared with T2DM without DN group, there was an increasing trend, but the difference was not significant (p> 0.05). In addition, serum CRp in T2DM with DN group was significantly higher than that in T2DM without DN group (p <0.05). Correlation analysis showed that there was a moderate positive correlation between serum resistin and CRP levels and the levels of FPG, FIns and Homa-IR in T2DM with DN (p <0.05). CONCLUSIONS: There is a moderate correlation between resistin and CRP and insulin resistance in patients with T2DM and DN. The dynamic monitoring of both can reflect the changes of patients’ condition to a certain extent.