Programmed death-1/programmed death-L1 signaling pathway and its blockade in hepatitis C virus immun

• 作 者: Mohamed L Salem Ahmed El-Badaw
• 机 构: CenterofExcellenceinCancerResearch,ImmunologyandBiotechnologyDivision,CenterofExcellenceforStemCells
• 出 处: 世界肝病学杂志：英文版（电子版）
• 发表日期: 2015年23期
• 关键词: HEPATITIS C virus Programmed death-1 HEPATITIS C v Hepatitis C virusProgrammed d
• 基金项目: Supported by Science and Technology Development Fund(STDF,grants No.1469 and No.5245),Tanta University Fund,Egypt to Mohamed L Salem,the Principal investigator of these projects

Chronic hepatitis C virus(HCV) infection is a public health issue that often progresses to life-threatening complications, including liver cirrhosis, fibrosis, and hepatocellular carcinoma. Impaired immune responses to HCV are key features of chronic HCV