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用顺铂（ＣＰ）诱发的大鼠急性肾功能衰竭（ＡＲＦ）动物实验模型，观察在急性肾功能衰竭发展的不同阶段血浆心钠素与肾素、血管紧张素系统之间的关系。发现在ＣＰ处置后２４、４８和７２ｈ，血清肌酐水平分别为正常对照组的１．５、２．５和４倍，同时血浆心钠素水平升高到１．８、２．７和３．６倍。而血浆肾素、血管紧张素系统的活性则相反，血浆肾素在２４ｈ末为正常对照组的２．５倍降低到４８ｈ的１．６倍，并于ＣＰ处置后７２ｈ恢复到正常对照组水平。血管紧张素在２４ｈ末为正常对照组４倍，在４８ｈ末下降４１％，７２ｈ末下降５８％，这表明在急性肾功能衰竭发展过程中，体内分泌的心钠素可能是通过拮抗肾素、血管紧张素系统从而起到肾功能保护的作用。
The experimental animal model of acute renal failure (ARF) induced by cisplatin (CP) in rats was used to observe the relationship between plasma atrial natriuretic peptide and renin, angiotensin system in different stages of the development of acute renal failure. Serum creatinine levels were found to be 1.5, 2.5 and 4 times higher than those in the normal control group at 24, 48 and 72 h after CP treatment, respectively, and plasma atrial natriuretic peptide levels increased to 1.8, 2.7 and 3 at the same time. 6 times. The activities of plasma renin and angiotensin system were opposite. Plasma renin decreased to 2.5 times that of the normal control group at the end of 24 hours to 1.6 times of that of 48h and recovered to the level of the normal control group at 72 hours after CP treatment . Angiotensin was 4-fold at the end of 24h, decreased by 41% at the end of 48h and decreased by 58% at the end of 72h. This indicates that in the process of acute renal failure, the secretion of atrial natriuretic peptide may be antagonized by renin, Angiotensin system thus play a role in renal function protection.