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本文对比观察鼻腔滴用0. 05％盐酸荼唑啉的豚鼠在普通饲料喂养和较大剂量补充维生素C和维生素B_2条件下,鼻腔呼吸区粘膜组织学及组织化学的变化情况。结果提示:单纯鼻腔滴用0. 05％盐酸萘唑啉能引起豚鼠鼻粘膜组织学及组织化学的明显改变,随用药时间的延长组织呈现退行性改变;而较大剂量补充维生素C和维生素B_2,则可明显减轻由萘唑啉引起的组织病理变化,且病变发生的时间推迟。说明该维生素有延缓和预防药物性鼻炎发生的作用。
This article compared the nasal cavity drops with 0.05% hydrochloric acid tazoxaline hydrochloride Guinea pig feeding in the general and larger doses of vitamin C and vitamin B 2 conditions, nasal respiratory area mucosal histology and histochemical changes. The results suggest that nasal drops of naphthalene hydrochloride alone can cause significant changes in the histology and histochemistry of nasal mucosa in guinea pigs with only 0.05% drop of naphthalene hydrochloride, and the degeneration of the tissues changes with the prolongation of drug use time; however, the larger doses of vitamin C and vitamin B_2 , The histopathological changes caused by naphazoline can be obviously alleviated and the time of occurrence of the lesions is delayed. Explain that the vitamin has the effect of delaying and preventing the occurrence of drug-induced rhinitis.