论文部分内容阅读
目的总结卵巢早衰患者的临床资料,探讨激素周期治疗卵巢早衰的临床效果。方法 2002年1月至2008年1月对我院门诊就诊的26例卵巢早衰患者行激素周期治疗3～6个周期,观察其临床表现,血清激素及阴道B超检查子宫的变化。结果 26例患者经雌孕激素治疗3～6个周期后,血清卵泡刺激素(FSH)、黄体生成素(LH)水平明显下降(P<0.01),血清雌二醇(E2)与服药前相比差异无统计学意义(P>0.05),与治疗前比较B超子宫横切面的横径、前后径有增厚(P<0.05),但子宫纵切面的长径与治疗前相比差异无统计学意义(P>0.05);与治疗前相比子宫内膜显著增厚(P<0.01)。22例患者症状缓解或消失,18例恢复月经,2例经克罗米芬促排卵治疗妊娠。结论卵巢早衰患者应尽早行激素周期治疗,有利于改善症状,有利于促排卵成功。
Objective To summarize the clinical data of patients with premature ovarian failure and investigate the clinical effect of hormone cycle treatment of premature ovarian failure. Methods From January 2002 to January 2008, 26 patients with premature ovarian failure in our clinic were treated with 3 ~ 6 cycles of hormone therapy. The clinical manifestations, changes of serum hormones and vaginal ultrasound were observed. Results Serum estradiol (FSH) and luteinizing hormone (LH) were significantly decreased in 26 patients after 3 to 6 cycles of estrogen and progesterone treatment (P <0.01) (P> 0.05). Compared with those before treatment, the transverse diameter and anteroposterior diameter of B-uterus had thickening (P <0.05), but there was no significant difference between the long diameter of longitudinal section of uterus and that before treatment The statistical significance (P> 0.05); Compared with before treatment, the endometrium was significantly thicker (P <0.01). Twenty-two patients had symptoms relieved or disappeared, 18 had menstruation recovered, and 2 had ovulation induction therapy by clomiphene. Conclusions Patients with premature ovarian failure should be treated with hormone cycle as soon as possible, which will help to improve symptoms and promote ovulation success.