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我国自一九七四年流脑提纯菌苗研制成功,经过四年多来的人体接种反应、血清学观察,以及安徽凤阳、江苏泰县等地百余万人的流行病学效果考核,证明固体培养制备的提纯菌苗人体免疫反应轻微,效果良好。但是,以固体培养生产菌苗的方法不适宜大
Since 1974, China has successfully developed mycobacterial purification vaccine. After more than four years of human inoculation reaction and serological observation, as well as the epidemiological assessment of more than one million people in Fengyang and Taixian, Jiangsu Province, It is proved that the purified vaccine produced by solid culture has slight human immune response and good effect. However, the method of producing bacterins by solid culture is not suitable