抗疟新药磷酸咯萘啶的合成

• 作 者: 陈昌
• 机 构: 中国医学科学院寄生虫病研究所,
• 出 处: 医药工业
• 发表日期: 1981年09期
• 关键词: 磷酸咯萘啶 抗疟 苯胺基 碳酸钠溶液 脑型疟 铁氰化钾 冰盐浴 肌内注射 氯化剂 生产工艺

本文简要介绍了抗疟新药磷酸咯萘啶的两种合成方法。方法A目前已通过生产工艺鉴定,但所用原料2-氨基吡啶价格昂贵,成本较高;方法B采用吡啶为起始原料,成本较低,且原料易得,但缺点是反应体积较大,后处理烦琐,氯化产率为43.9～48.2％,尚有待提高。

This article briefly introduced two new synthetic methods of antimalarial drug pyronaridine. Method A has been identified by the production process at present, but the raw material 2-aminopyridine is expensive and the cost is high. Method B uses pyridine as a starting material with low cost and easy-to-obtain raw materials, but the disadvantage is that the reaction volume is large, Processing cumbersome, chlorination yield 43.9 ~ 48.2%, yet to be improved.