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目的:探讨GnRH-a用于子宫内膜异位症术后的疗效。方法:选取因盆腔子宫内膜异位症合并不孕行保守性手术治疗后的患者112例,随机分为两组。观察组60例,对照组52例,观察组患者术后应用促性腺激素释放激素类似物(GnRH.a),对照组术后不用药。观察术后两组患者的临床疗效、不同期别的术后复发和妊娠情况。结果:对照组、观察组术后年复发率及临床症状缓解率差异明显;轻度(Ⅰ期-Ⅱ期)患者,对照组和观察组的年复发率及妊娠率差异不明显;中、重度(Ⅲ期-Ⅳ期)患者两组的复发率及妊娠率,差异有显著性。结论:对于I期一II期患者,术后是否应用GnRH.a可视病情需要,而对III期、Ⅳ期患者术后追加GnRH.a的治疗非常必要,可预防复发和提高停药后的妊娠率。
Objective: To investigate the efficacy of GnRH-a for postoperative endometriosis. Methods: 112 patients with conservative treatment of pelvic endometriosis complicated with infertility were selected and randomly divided into two groups. 60 cases in the observation group and 52 cases in the control group. The patients in the observation group were given GnRH.a after operation and the patients in the control group were given no medicine after operation. To observe the clinical efficacy of two groups of patients after surgery, different stages of postoperative recurrence and pregnancy. Results: The annual recurrence rate and clinical symptom relief rate in the control group and the observation group were significantly different. The mild recurrence (Ⅰ-Ⅱ), the control group and the observation group had no significant difference in the annual recurrence rate and pregnancy rate. The moderate and severe (Stage Ⅲ-Ⅳ) patients in both groups, the recurrence rate and pregnancy rate, the difference was significant. Conclusions: It is necessary to treat GnRH.a in stage I-II patients after surgery, and it is necessary to treat GnRH.a in stage III and IV patients after surgery, which can prevent relapse and improve Pregnancy rate.