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目的了解哈尔滨市香坊区1~6岁儿童麻疹的血清学免疫水平,为进一步调整免疫策略提供依据。方法随机抽取香坊区1~6岁儿童924人,进行问卷调查并采集末梢血,采用酶联免疫吸附试验(ELISA)检测麻疹病毒IgG抗体水平,应用统计学软件对不同人群进行比较分析。结果香坊区1~6岁儿童的麻疹抗体阳性率为90.3%。不同年龄和不同来源儿童麻疹抗体水平差异有统计学意义(χ~2分别为28.958和21.915,P均<0.01),且有随接种次数增多抗体阳性率增高的趋势(χ~2=53.332,P<0.01);不同社区和不同性别儿童麻疹抗体阳性率差异无统计学意义(χ~2分别为1.407和0.960,P均>0.05)。结论哈尔滨市香坊区1~6岁儿童麻疹抗体阳性率高于90%,能够形成有效的免疫屏障。
Objective To understand the serological immunity level of measles in children aged 1 ~ 6 years in Xiangfang District, Harbin, and to provide basis for further adjustment of immunization strategy. Methods A total of 924 children aged 1 ~ 6 years were collected from Xiangfang District for questionnaire survey and peripheral blood was collected. ELISA was used to detect the level of IgG antibody in measles virus. Statistical software was used to compare different groups. Results The positive rate of measles antibody in children aged 1 ~ 6 years in Xiangfang District was 90.3%. The antibody level of measles in children of different ages and different sources was statistically significant (χ ~ 2 = 28.958 and 21.915, P <0.01), and the positive rate of antibody increased with the number of inoculation (χ ~ 2 = 53.332, P <0.01). There was no significant difference in the positive rate of measles antibody between children of different communities and different sex (χ ~ 2 = 1.407 and 0.960, P> 0.05). Conclusion The positive rate of measles antibody in children aged 1 ~ 6 years in Xiangfang District of Harbin is higher than 90%, which can form an effective immune barrier.