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肝脏对维生素D代谢具有重要作用,因为维生素D在进一步活化或失活之前必须在肝脏羟化为25—OHD_3,调节维生素D代谢物贮存和生物效力的血清维生素结合蛋白(DBP)也是在肝脏合成的。此外,肝脏也是使完整的PTH转变为具有生物活性和非活性片段的重要代谢场所。因此长期肝病病人可患有骨和矿物质紊乱疾病如骨质疏松、软骨病。目前对这类紊乱的发病机制还没有完全阐明,
The liver plays an important role in vitamin D metabolism because vitamin D must be hydroxylated 25-OHD 3 in the liver before further activation or inactivation, and serum vitamin-binding protein (DBP), which regulates vitamin D metabolite storage and bioefficacy, is also synthesized in the liver of. In addition, the liver also converts the intact PTH into an important metabolic site with biologically active and inactive fragments. Therefore, patients with chronic liver disease may have bone and mineral disorders such as osteoporosis and rickets. The current pathogenesis of such disorders has not been fully elucidated,