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地高辛(Digo xin,以下简和)是治疗心力衰竭及心律失常的重要药物。但其安全范围较小(治疗量约为中毒量的60％),剂量因个体差异变化也较大,故为毒性反应较多的药物,同时也是10种发生相互作用最多的药物之一。据报道,因D的相互作用而出现的不良反应发生率约为27％。临床上往往将这种毒副作用误认为是D本身的中毒反应。为此,本文就D在合并用药中的相互作用简述如下,以供临床参考。奎尼丁据不同的观察,已用D者,若加用奎尼丁,可使血清地高辛浓度(下称SDC)
Digoxin is an important drug for the treatment of heart failure and arrhythmia. However, its safety range is relatively small (treatment volume is about 60% of the dose of poisoning). Since dosage varies greatly due to individual differences, it is one of the 10 drugs that cause more toxic reactions and also have the most interactions with each other. It is reported that the incidence of adverse reactions due to the interaction of D is about 27%. Clinically, this toxic side effects are often mistaken for D itself poisoning reaction. To this end, this article on the D drug combination in the interaction is summarized as follows, for clinical reference. According to different observations of quinidine, D has been used, if combined with quinidine, serum digoxin concentration (hereinafter referred to as SDC)