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目的观察高原低氧环境暴露下脑内脂质过氧化物的代谢变化，进一步探讨高原性脑水肿的发生机理。方法在兰州（海拔１５１７ｍ）、格尔木（海拔２８００ｍ）和昆仑山口（海拔４７６７ｍ）三个不同海拔梯度下和高海拔区（昆仑山口）的不同时间（１、３、５、７、９、１１、１３、１５ｄ）暴露下分别观察了小鼠脑内超氧化物歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ）、谷胱甘肽过氧化物酶（ＧＳＨ—ＰＸ）和谷胱甘肽（ＧＳＨ）的变化。结果小鼠急进高海拔区后，随着海拔升高，脑内抗氧化能力加强，ＳＯＤ含量逐渐升高，ＭＤＡ逐渐降低，ＧＳＨ—ＰＸ明显降低，而ＧＳＨ明显增高，但在进入中海拔区后ＧＳＨ—ＰＸ和ＧＳＨ增高，差异均非常显著（Ｐ＜０．０１）。小鼠由低海拔区急进高海拔区后脑内超氧化物歧化酶（ＳＯＤ）水平随着时间延长呈增高趋势，与兰州地区测值比较均有显著性差异（Ｐ＜０．０５，Ｐ＜０．０１）。丙二醛（ＭＤＡ）水平始终持平，无显著性变化。但谷胱甘肽过氧化物酶（ＧＸＨ—ＰＸ）水平在进入高原第１ｄ明显降低，随后又升高到接近于基础水平，至进入高原第５ｄ开始呈持续下降趋势，直到第１５ｄ始终低于第５ｄ水平，与第３ｄ比较差异的非常显著（Ｐ＜０．０１）。谷脱甘肽（ＧＳＨ）水平?
Objective To observe the changes of brain lipid peroxides in exposure to high altitude hypoxic environment and to explore the pathogenesis of high altitude brain edema. Methods Three different altitudinal gradients of Lanzhou (1517m above sea level), Golmud (above sea level 2800m) and the Kunlun Pass (4767m above sea level) and at different altitudes (1, 3, 5, 7, 9, The contents of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-PX) and glutathione (GSH) The change. Results After the mice were eased into the high altitude area, with the elevation of altitude, the antioxidant capacity of the brain increased, the content of SOD gradually increased, the MDA decreased gradually, the GSH-PX decreased significantly and the GSH increased obviously. However, after entering the middle altitude area GSH-PX and GSH increased, the difference was significant (P <0.01). The level of superoxide dismutase (SOD) in the brain increased gradually with the increase of time from low altitude region to high altitude region, and there was a significant difference compared with the measured values in Lanzhou (P <0.05, P <0 .01). Malondialdehyde (MDA) level remained unchanged, no significant change. However, the level of glutathione peroxidase (GXH-PX) decreased significantly on the 1st day after entering the plateau and then increased to a level close to the basal level, and continued to decline from the 5th day after entering the plateau until the 15th day The level of 5d was significantly different from that of 3d (P <0.01). Glutamate (GSH) levels?