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目的评价肌肉注射和宫颈注射卡前列素氨丁三醇两种方式治疗产后出血的临床疗效。方法将460例产后出血患者,随机分为对照组318例与实验组142例。对照组手臂三角肌肌肉注射卡前列素氨丁三醇注射液250μg,而实验组宫颈注射相同剂量的卡前列素氨丁三醇注射液。比较对照组与实验组患者在第三产程结束后2 h内子宫出血量、阴道出血量以及产后不良反应率。结果实验组子宫出血量平均为(71.43±13.96)ml,对照组的子宫出血量为(50.56±10.78)ml,两组比较有统计学差异(P<0.05);实验组的阴道出血量(35.31±6.32)ml,对照组的阴道出血量(44.27±8.31)ml,两组比较有统计学差异(P<0.05);实验组不良反应发生率为16.12%,对照组不良反应发生率为11.66%,两组间无统计学差异(P>0.05)。结论子宫收缩乏力产妇建议采取手臂三角肌肌肉注射预防和治疗产后出血;其他类型产妇建议采取宫颈注射预防产后出血。
Objective To evaluate the clinical efficacy of intramuscular and cervical injection of carboprost trometamol in two ways to treat postpartum hemorrhage. Methods 460 cases of postpartum hemorrhage were randomly divided into control group of 318 cases and experimental group of 142 cases. Control group arm deltoid muscle intramuscular injection of cardoprost trometamol injection 250μg, while the experimental group of cervical injection of the same dose of carboprost tromethamine injection. The amount of uterine bleeding, the amount of vaginal bleeding and the rate of postpartum adverse reactions within 2 hours after the end of the third stage of labor were compared between the control group and the experimental group. Results The mean amount of uterine bleeding in the experimental group was (71.43 ± 13.96) ml and that in the control group was (50.56 ± 10.78) ml, the difference was statistically significant (P <0.05). The amount of vaginal bleeding in the experimental group was 35.31 ± 6.32) ml, and the amount of vaginal bleeding in the control group (44.27 ± 8.31) ml was statistically significant (P <0.05). The incidence of adverse reactions in the experimental group was 16.12% and the incidence of adverse reactions in the control group was 11.66% , No significant difference between the two groups (P> 0.05). Conclusions It is suggested that intramuscular injection of arm deltoid muscles to prevent and treat postpartum hemorrhage should be taken by women with uterine atony. Other types of maternal women are advised to take cervical injection to prevent postpartum hemorrhage.