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制备了丙酸倍氯米松醋酸乙酯溶剂化物（１）及其微粉，用以制备丙酸倍氯米松混悬型气雾剂。分别对１及微粉的理化性质和制备的气雾剂的行为进行了考察。Ｘ衍射、热重分析及红外光谱测定结果证实醋酸乙酯以结合形式存在于１中。ＥｔＯＡｃ／１结合百分比约为９％。采用微粉化工艺制得３批样品的粒径分别为１．６８±０．６２、２．３４±１．６３、２．４４±０．５６μｍ。且微粉化过程无结合溶剂损失及晶型转化发生。外冲程实验表明，该气雾剂在肺深部的沉积达４５％以上。
Beclomethasone acetate ethyl acetate solvate (1) and its fine powder were prepared for the preparation of beclomethasone propionate aerosol. The physical and chemical properties of 1 and the micropowder and the prepared aerosol behavior were investigated respectively. X-ray diffraction, thermogravimetric analysis and infrared spectroscopy confirmed that ethyl acetate was present in the bound form. The EtOAc / 1 binding percentage is about 9%. The particle size of three batches of samples obtained by the micronization process were 1.68 ± 0.62, 2.34 ± 1.63 and 2.44 ± 0.56μm, respectively. And the micronization process without loss of solvent and crystalline conversion occurs. External stroke experiments show that the aerosol deposition in the deep lung more than 45%.