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目的观察口服避孕药联合二甲双胍治疗多囊卵巢综合征(PCOS)的疗效。方法选择2001年11月至2004年6月在昆明医学院第一附属医院就诊的PCOS患者90例,随机分为A、B、C3组。A组32例,口服妈富隆联合二甲双胍治疗;B组40例,口服达因-35联合二甲双胍治疗;C组18例,单用妈富隆治疗。3组用药时间均为3个月。测定患者血清卵泡刺激素(FSH)、黄体生成素(LH)和睾酮(T),测量腰/臀比值(WHR)及体质指数(BMI)并进行治疗前后的比较。结果A、B两组治疗后LH、LH/FSH、T及WHR均较治疗前明显降低(P<0.05或P<0.01)且两组间差异无显著性(P>0.05);C组治疗后LH、LH/FSH、T较治疗前明显降低(P<0.01),但WHR明显升高(P<0.05)。A、B、C3组治疗后各项指标比较LH、LH/FSH及T差异无显著性(P>0.05),而C组WHR明显高于A、B两组(P<0.01)。结论口服避孕药联合二甲双胍治疗PCOS疗效优于单用口服避孕药。妈富隆与达因-35疗效比较,差异无显著性。
Objective To observe the efficacy of oral contraceptives combined with metformin in the treatment of polycystic ovary syndrome (PCOS). Methods Ninety patients with PCOS who were treated in the First Affiliated Hospital of Kunming Medical College from November 2001 to June 2004 were randomly divided into A, B and C3 groups. A group of 32 patients, oral Marvelon combined with metformin treatment; B group 40 cases, oral darin -35 combined with metformin treatment; C group 18 cases, only Marvelon treatment. 3 groups were treated for 3 months. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (T) were measured before and after treatment to measure the ratio of waist to hip (WHR) and body mass index (BMI). Results After treatment, the LH, LH / FSH, T and WHR in both groups were significantly lower than those before treatment (P <0.05 or P <0.01), and there was no significant difference between the two groups (P> 0.05) LH, LH / FSH, T were significantly lower than before treatment (P <0.01), but WHR was significantly increased (P <0.05). The indexes of LH, LH / FSH and T in group A, B and C3 after treatment showed no significant difference (P> 0.05), while the WHR in group C was significantly higher than that of group A and B (P <0.01). Conclusion Oral contraceptives combined with metformin in the treatment of PCOS is superior to single oral contraceptives. Marvelon and Darin -35 efficacy comparison, the difference was not significant.