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目的 观察血管紧张素受体拮抗剂氯沙坦对糖尿病肾病病人尿蛋白排泄的影响。方法 选择 4 7例血压控制良好的糖尿病肾病病人 ,并设置相应对照组 ,治疗组用氯沙坦每天 5 0mg ,观察治疗前及治疗后 1个月、3个月、6个月的尿白蛋白排泄以及其他生化指标的变化。结果 治疗组用氯沙坦后 1个月、3个月、6个月的尿白蛋白排泄均有显著下降 (组内配对比较 ,P <0 .0 1) ,与对照组比较亦有显著性差异 (P <0 .0 1)。结论 氯沙坦具有不依赖其降压作用而降低糖尿病肾病的尿白蛋白排泄的作用。
Objective To observe the effect of losartan, an angiotensin receptor antagonist, on urinary protein excretion in patients with diabetic nephropathy. Methods Forty seven patients with well-controlled diabetic nephropathy were enrolled in this study. Patients in the treatment group were treated with losartan 50 mg daily. The levels of urinary albumin (ALB) before treatment, 1 month, 3 months and 6 months after treatment were observed. Excretion and other biochemical changes. Results The urinary albumin excretion of the treatment group decreased significantly with losartan 1 month, 3 months and 6 months after treatment (paired comparison, P <0.01), and significant difference compared with the control group Difference (P <0. 01). Conclusion Losartan has the effect of reducing urinary albumin excretion of diabetic nephropathy independent of its antihypertensive effect.