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目的:探讨血清降钙素原在急性胰腺炎中的诊断价值及其对抗生素早期治疗的指导意义。方法:选取2013年2月-2015年2月中山市板芙医院确诊并收治的急性胰腺炎患者25例,其中轻症急性胰腺炎(MAP)患者13例、重症急性胰腺炎(SAP)患者12例,选取同期体检健康者25例作为正常对照组,测定血清降钙素原水平。结果:MAP组、SAP组入院第1天血清中降钙素原水平明显高于正常对照组,且入院后第2天、第7天SAP组血清中降钙素原水平明显高于MAP组,组间比较,差异具有统计学意义(P<0.05);急性胰腺炎组C反应蛋白(CRP)水平、白细胞计数(WBC)及APACHE-Ⅱ评分情况与正常对照组相比,差异无统计学意义(P>0.05)。结论:血清降钙素原在急性胰腺炎诊断中具有较好的应用价值,其能够为抗生素治疗急性胰腺炎提供重要指导,可明显改善预后。
Objective: To investigate the diagnostic value of serum procalcitonin in acute pancreatitis and its guiding significance for the early treatment of antibiotics. Methods: Twenty-five patients with acute pancreatitis confirmed and treated at Banff Hospital of Zhongshan City from February 2013 to February 2015 were selected. Among them, 13 were patients with mild acute pancreatitis (MAP), 12 with severe acute pancreatitis (SAP) For example, select 25 cases of healthy people in the same period as the normal control group, and measure serum procalcitonin level. Results: Serum procalcitonin levels of MAP group and SAP group were significantly higher than those of normal control group on the first day of admission, and the level of procalcitonin in SAP group was significantly higher than MAP group on the 2nd day and the 7th day after admission, The difference between the two groups was statistically significant (P <0.05). The CRP, WBC and APACHE-Ⅱ scores in acute pancreatitis group were not significantly different from those in normal control group (P> 0.05). Conclusion: Serum procalcitonin has a good value in the diagnosis of acute pancreatitis. It can provide important guidance for the treatment of acute pancreatitis by antibiotics, and can significantly improve the prognosis.