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给犬iv青蒿酯钠每天一次,连续14d,90mg/kg使全部动物中毒死亡,45mg/kg中毒表现明显,2/6犬死亡,22.5mg/kg出现轻度中毒,11.25mg/kg未见明显毒副作用,可视为基本安全剂量。毒性作用的主要症状表现为呕吐、摄食量减少,重者出现粘液血便等;心电图Q-T间期延长,Q-T比值增大;化验及病理检查显示骨髓造血抑制,首先是红系成熟障碍,胆汁淤滞,内脏淤血,45mg/kg以上剂量还出现粒系成熟障碍及心、肝、肾、胃肠道、视网膜等组织实质性损伤及相应的血液学和血液生化变化。血液网织红细胞减少或消失仍是最敏感的指标。停药后28d各种变化基本恢复正常。
Dog iv iv sodium ether once a day for 14 days, 90mg / kg so that all animals died of poisoning, 45mg / kg poisoning significantly, 2/6 dogs died, 22.5mg / kg mild poisoning, 11.25mg / kg no Obvious toxic side effects, can be regarded as the basic safe dose. Toxicity of the main symptoms of vomiting, decreased food intake, severe cases of mucus bloody; ECG QT prolongation, QT ratio increased; laboratory and pathological examination showed hematopoietic inhibition of bone marrow, the first erythroid maturation disorder, cholestasis, Visceral congestion, more than 45mg / kg dose also appeared maturity and the maturity of the heart, liver, kidney, gastrointestinal tract, retinal tissue and other substantial damage and the corresponding hematological and blood biochemical changes. Blood reticulocytes decreased or disappeared is still the most sensitive indicator. 28d after stopping all kinds of changes returned to normal.