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目的探讨戊唑醇原药的诱变性及亚慢性毒性作用。方法按照我国GB15670-1995《农药登记毒理学试验方法》要求进行。结果 62.5~250μg/皿的Ames实验结果为阴性;染毒14.7~294 mg/kg的剂量组微核试验结果为阴性;染毒36.8~147 mg/kg的剂量组的小鼠睾丸精母细胞染色体畸变率未见增加;亚慢性经口毒性试验高剂量组(71.7mg/kg.bw/d)的雄鼠在染毒中后期出现精神不振、少动、被毛蓬松、会阴部污秽等中毒症状。结论戊唑醇原药无明显致突变作用。戊唑醇原药有一定的蓄积毒性作用,可引起潜在的慢性中毒,主要的毒作用部位是肝脏与血液系统。戊唑醇原药SD雌、雄大鼠亚慢性(90 d)经口试验未观察到有害效应的剂量水平分别为16.3、8.0 mg/kg.bw/d。
Objective To investigate the mutagenicity and subchronic toxicity of tebuconazole. Methods according to China’s GB15670-1995 “pesticide registration toxicology test method” requirements. Results The Ames test results of 62.5 ~ 250μg / dish were negative; the micronucleus test results of the dose group of 14.7 ~ 294 mg / kg were negative; the testicular spermatocyte chromosome of 36.8 ~ 147 mg / kg The rate of distortion did not increase; Subchronic oral toxicity test of high-dose group (71.7mg / kg.bw / d) of male rats in the late post-exposure appeared in a sluggish, less moving, fluffy hair, perineal contamination and other symptoms of poisoning . Conclusion Tebuconazole the original drug has no obvious mutagenic effect. Tebuconazole original drug has a certain accumulation of toxic effects, can cause potential chronic poisoning, the main site of toxic effects of liver and blood system. Tebuconazole original drug SD female and male rats subchronic (90 d) oral test no harmful effects were observed dose levels were 16.3,8.0 mg / kg.bw / d.