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目的观察高血压急症患者使用尼卡地平注射剂有效控制血压后逐渐减量并过渡为尼卡地平缓释胶囊的临床有效性及安全性。方法入选住院高血压急症患者103例使用尼卡地平注射剂降压至目标血压后,随机分为口服尼卡地平缓释胶囊和硝苯地平缓释片组,逐渐减少注射剂用量直至停用,继续监测血压5日。结果入选患者使用尼卡地平注射剂后,血压下降显著(P<0.01),显效率81.6%,有效率16.5%。心率较治疗前无明显变化(P>0.05),无明显不良反应。尼卡地平缓释胶囊组患者血压平稳过渡率及平稳过渡且良好控制率分别为90%和81.7%,明显高于硝苯地平缓释片组71.7%(P<0.05)和48.8%(P<0.01)。结论尼卡地平注射剂及缓释胶囊可良好控制高血压急症和平稳维持血压。
Objective To observe the clinical efficacy and safety of nicardipine sustained-release capsules after gradual tapering with nicardipine injection in hypertensive patients. Methods A total of 103 hospitalized hypertensive patients were treated with nicardipine injection to target blood pressure and then randomly divided into oral nicardipine sustained release capsules and nifedipine sustained release tablets. Blood pressure on the 5th. Results After the patients were given nicardipine injection, the blood pressure dropped significantly (P <0.01), the effective rate was 81.6% and the effective rate was 16.5%. No significant changes in heart rate before treatment (P> 0.05), no significant adverse reactions. The smooth transition rate and smooth transition of patients with sustained release of nicardipine capsules were 90% and 81.7%, respectively, which were significantly higher than that of nifedipine sustained-release tablets 71.7% (P <0.05) and 48.8% (P < 0.01). Conclusion Nicardipine injection and sustained-release capsules can control acute hypertension and maintain blood pressure smoothly.