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目的探讨提高Ⅲ期非小细胞肺癌治疗效果的方法。方法85例Ⅲ期非小细胞肺癌患者随机分为3组,并进行不同顺序的治疗,A组(化疗+手术+放疗)28例,放疗后配合辅助化疗;B组(手术+化疗+放疗)28例;C组(手术+放疗+化疗)29例。比较各组3年生存率、局部区域复发率和远处转移率的差异性。结果A、B、C3组3年生存率分别为75.00%,53.57%,44.83%,其中A组与C组比较差异有显著性意义(P<0.05);3组局部区域复发率分别为7.14%,32.14%,17.24%,其中A组与B组比较差异有显著性意义(P<0.05);各组远处转移率分别为7.14%,10.71%,37.93%,其中A组与C组及B组与C组比较,差异均有显著性意义(P<0.05)。结论术前化疗再手术,配合术后放疗及辅助化疗,可提高治疗Ⅲ期非小细胞肺癌的疗效。
Objective To explore ways to improve the treatment effect of stage Ⅲ non-small cell lung cancer. Methods A total of 85 patients with stage Ⅲ non-small cell lung cancer were randomly divided into 3 groups and treated with different sequences. A group (Chemotherapy + Surgery + Radiotherapy) 28 patients received radiotherapy combined with adjuvant chemotherapy; B group (operation + chemotherapy + radiotherapy) 28 cases; C group (surgery + radiotherapy + chemotherapy) in 29 cases. The differences of 3-year survival rate, local recurrence rate and distant metastasis rate in each group were compared. Results The 3-year survival rates of A, B and C3 groups were 75.00%, 53.57% and 44.83%, respectively. There was significant difference between group A and group C (P <0.05). The recurrence rates of three groups were 7.14% , 32.14% and 17.24%, respectively. There was a significant difference between group A and group B (P <0.05). The distant metastasis rate of each group was 7.14%, 10.71% and 37.93% There was significant difference between group C and group C (P <0.05). Conclusions The reoperation of preoperative chemotherapy combined with postoperative radiotherapy and adjuvant chemotherapy can improve the efficacy of treatment of stage Ⅲ non-small cell lung cancer.