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根据动物实验发现,脑内注射β-内啡肽可以产生类似精神分裂症患者出现的肌强直,以及在精神分裂症患者脑脊液中内啡肽的活性高于正常人。作者用纳洛酮对10例精神分裂症患者(男女各半,病程1～12年)进行了治疗,每天给药4次,每次皮下注射盐酸纳洛酮0.1毫克(0.25毫升),连续给药一周,观察疗效,此时不用其它药物。另在5例患者于治疗前后抽取脑脊液。用放射受体结合法测定脑脊液中吗啡样物质的活性。治疗结果表明,除3名(其中一人未完成治疗)外,其余患者均获得不同程度的疗效,而以猜疑、幻觉等症状的改
According to animal experiments, intracerebral injection of [beta] -endorphin can produce myotonia similar to schizophrenia patients, and the activity of endorphins in cerebrospinal fluid of schizophrenia patients is higher than that of normal people. The authors used naloxone 10 patients with schizophrenia (male and female half, duration of 1 to 12 years) were treated 4 times a day, each subcutaneous injection of naloxone hydrochloride 0.1 mg (0.25 ml), continuous A week of medicine, observe the effect, this time without other drugs. The other 5 patients were drawn before and after treatment of cerebrospinal fluid. Determination of morphine-like activity in cerebrospinal fluid by radioimmunoassay. Treatment results show that, in addition to 3 (one of whom did not complete treatment), the rest of the patients received varying degrees of efficacy, and suspicion, hallucinations and other symptoms of change