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为探讨白藜三醇的抗脂质氧化作用及其可能机制，采用Ｃｕ２＋和２，２＇－盐酸脒基丙烷两种不同的氧化体系诱导正常人低密度脂蛋白的氧化反应，应用硫代巴比妥酸法测定低密度脂蛋白氧化过程中硫代巴比妥酸反应物质和氧化型低密度脂蛋白的相对电泳迁移率的变化。结果发现５０μｍｏｌ／Ｌ白藜三醇可使Ｃｕ２＋介导的低密度脂蛋白氧化反应明显减弱，其硫代巴比妥酸反应物质和相对电泳迁移率分别下降７０．５％和４２．３％（Ｐ＜０．０１）；同时白藜三醇使Ｃｕ２＋和２，２＇－盐酸脒基丙烷诱导的低密度脂蛋白氧化反应潜伏期延长。上述结果提示白藜三醇具有抑制低密度脂蛋白氧化反应作用，推测其作用机制可能与捕获自由基等有关。
In order to explore the anti-lipid oxidation of resveratrol and its possible mechanism, two kinds of oxidative systems, Cu2 + and 2,2’-amidinopropane hydrochloride, were used to induce the oxidation of normal human LDL. The relative electrophoretic mobilities of thiobarbituric acid-reactive substances and oxidized low-density lipoproteins during the process of low-density lipoprotein oxidation were determined by the method of tautidine. The results showed that 50μmol / L resveratrol could significantly reduce Cu2 + -mediated LDL oxidation, the thiobarbituric acid-reactive substances and relative electrophoretic mobility decreased by 70.5% and 42.3% respectively P <0.01). Simultaneously, the latency of LDL oxidation induced by Cu2 + and 2,2’-amidinopropane hydrochloride was prolonged by resveratrol. The above results suggest that resveratrol can inhibit the LDL oxidation reaction, suggesting that its mechanism of action may be related to the capture of free radicals.