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目的采用沙利度胺联合改良VAD方案治疗老年多发性骨髓瘤18例,评价其疗效和安全性。方法沙利度胺联合经改良的VAD方案(吡喃阿霉素替代阿霉素、地塞米松减为19.5 mg/d),观察疗效和药物不良反应。结果本方案治疗多发性骨髓瘤总有效率94.4%,不良反应轻微。结论沙利度胺联合经改良的VAD方案对于老年患者是疗效较好,不良反应可耐受,值得临床推广的方案。
Objective To evaluate the efficacy and safety of thalidomide combined with modified VAD regimen in the treatment of 18 elderly patients with multiple myeloma. Methods Thalidomide combined with modified VAD regimen (praziquantel instead of adriamycin, dexamethasone reduced to 19.5 mg / d), efficacy and adverse drug reactions were observed. Results The total effective rate of the treatment of multiple myeloma 94.4%, mild adverse reactions. Conclusions Thalidomide combined with modified VAD regimen is effective in elderly patients with adverse reactions and is worthy of clinical promotion.