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目的:比较布拉酵母菌散与双歧杆菌三联活菌胶囊佐治小儿下呼吸道感染抗生素相关性腹泻(AAD)的疗效。方法:将85例下呼吸道感染ADD患儿按随机数字表法分为A组42例和B组43例,均停用原抗菌药物,统一换用头孢唑肟钠。同时给予补液盐(ORS)、维生素、锌制剂以纠正水、电解质紊乱,口服蒙脱石散保护胃肠粘膜。A组加用双歧杆菌三联活菌胶囊每次210~420 mg(1~2粒),3次/天;B组加用布拉酵母菌散每次125~250 mg,1~2次/天。两组均持续治疗7 d,观察治疗效果及不良反应。结果:B组总有效率93.02%,高于A组的73.81%(P<0.05);B组腹泻持续时间(3.1±1.0)d,短于A组的(4.3±1.4)d(P<0.01)。B组3例出现轻微不良反应,A组未发现明显不良反应。结论:布拉酵母菌散佐治小儿下呼吸道感染AAD,可有效改善患儿肠道微生态环境,缩短腹泻时间,疗效优于双歧杆菌三联活菌胶囊。
Objective: To compare the curative effect of Bacto-Saccharomyces cerevisiae and antibiotic-associated diarrhea (AAD) treated with Bifidobacterium triple viable capsule in children with lower respiratory tract infection. Methods: Eighty-five cases of ADD in children with lower respiratory tract infection were divided into 42 cases in group A and 43 cases in group B according to the random number table. All patients were discontinued with the original antibacterial drugs and switched to ceftizoxime sodium. At the same time given rehydration salts (ORS), vitamins, zinc preparations to correct water and electrolyte disorders, oral montmorillonite powder to protect the gastrointestinal mucosa. A group with bifidobacterium triple viable capsules each time 210 ~ 420 mg (1 ~ 2 tablets), 3 times / day; B group with Saccharomyces cerevisiae each 125 ~ 250 mg, 1 ~ 2 times / day. Both groups continued treatment for 7 days to observe the therapeutic effect and adverse reactions. Results: The total effective rate in group B was 93.02%, which was higher than 73.81% in group A (P <0.05). The duration of diarrhea in group B was (3.1 ± 1.0) d, shorter than that in group A (4.3 ± 1.4) d ). B group 3 patients showed mild adverse reactions, A group did not find significant adverse reactions. Conclusion: Bladder yeast dispersal adjuvant AAD in children with lower respiratory tract infection can effectively improve intestinal microflora in children and shorten the diarrhea time, the effect is better than Bifidobacterium triple viable capsule.