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本文就国产溴苄乙铵进行了药理观察,证实了前人报告的降压作用以及对交感神经的选择作用,并发现用药后交感末梢的介质释放量显著减少;大剂量能明显改变猫、兔在位心脏的功能;在一般降压剂量时不仅增敏儿茶酚胺的升压作用,并且也能增敏其降压作用。初步试验了溴苄乙铵的异构体与类似物5个,发现间位与对位异构体同溴苄乙胺(邻位)对血压的作用相反,用药后血压略降后卽显著上升,并伴有瞬膜收缩和唾液分泌增加,阿托品能取消其降压和唾液分泌作用,而溴苄乙铵则能取消其升压作用。
In this paper, pharmacological observation of domestic bromobenzethonium was carried out, which confirmed the hypotensive effect and the selective effect on sympathetic nerves reported in the past and found that the release of mediators in the sympathetic terminals was significantly reduced after treatment. The high dose could significantly change the cats and rabbits Heart function in place; not only in the general antihypertensive dose of sensitizing catecholamine boost, but also can enhance its antihypertensive effect. A preliminary trial of 5 benzyl isethionate isomers and analogues and found that the meta and para isomers with bromobenzethylamine (ortho) on the opposite effect on blood pressure, blood pressure slightly lower after treatment 卽 significantly increased , Accompanied by transient membrane contraction and increased salivary secretion, atropine to cancel its antihypertensive and salivary secretion, while the benzyl bromide can cancel its booster effect.