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肝纤维化是多种慢性肝病共有的组织改变 ,肝纤维化的发生与肝 Kupffer细胞被激活后释放大量细胞因子 ,激活肝星状细胞 (HSC)产生大量胶原 ,导致细胞外基质 (ECM)的形成与降解失衡 ,ECM过度沉积等密切相关。细胞因子在肝纤维化中的作用是当前肝纤维化研究的活跃领域 ,TGF- β是
Liver fibrosis is a common tissue alteration in a variety of chronic liver diseases. The development of hepatic fibrosis is associated with the release of a large number of cytokines when activated by hepatic Kupffer cells, activation of hepatic stellate cells (HSCs) to produce large amounts of collagen, leading to extracellular matrix (ECM) Formation and degradation of imbalance, ECM is closely related to excessive deposition. The role of cytokines in liver fibrosis is an active field of current liver fibrosis research where TGF- [beta] is