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目的:探讨茵陈蒿汤加减方对哮喘气道转化生长因子-β1(TGF-β1)的干预机制。方法:制备大鼠哮喘模型,模型动物随机分为四个组:模型组、西药(地塞米松)组、中药组,空白对照组,每组10只大鼠。从第17天起开始给予相应药液灌胃,西药组给予地塞米松1 g/kg,中药组给予茵陈蒿汤加减方配方颗粒溶液(浓度0.5 g/m L)5 m L/kg,每日1次。空白对照组和模型组分别以等量的生理盐水灌胃,每周按照大鼠体重调整1次。连续给药干预4周,检测血清中TGF-β1含量并进行比较分析。结果:中药组与西药组均可降低TGF-β1的含量,与模型组比较有显著性差异(P<0.01),中药组与西药组效果相当(P>0.05)。结论:茵陈蒿汤加减方能通过有效地减低大鼠血清中TGF-β1的含量,从而阻断气道重塑的发生,达到预防和缓解哮喘的治疗目的。
Objective: To investigate the mechanism of Yinchenhao decoction on asthma airway transforming growth factor-β1 (TGF-β1) intervention. Methods: The rat asthma model was prepared. The model animals were randomly divided into four groups: model group, western medicine (dexamethasone) group, traditional Chinese medicine group and blank control group, with 10 rats in each group. From the 17th day onwards, the corresponding medicinal solution was given orally, and the western medicine group was given dexamethasone 1 g / kg. The Chinese medicine group was given Yinchenhao decoction formula granule solution (concentration 0.5 g / m L) 5 m L / kg, 1 day. Blank control group and model group were given the same amount of normal saline, weekly body weight adjusted 1 time. Continuous administration intervention for 4 weeks, serum TGF-β1 levels and comparative analysis. Results: Both the traditional Chinese medicine group and the western medicine group could reduce the content of TGF-β1, which was significantly different from the model group (P <0.01). The Chinese medicine group and the western medicine group had the same effect (P> 0.05). Conclusion: Yinchenhao decoction can effectively prevent the decrease of airway remodeling by effectively reducing the content of TGF-β1 in rat serum and achieve the goal of preventing and relieving asthma.