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已有不少脾淋巴瘤的报告,但包括了许多晚期疾病(同时有肝淋巴瘤浸润和/或广泛的腹部淋巴结累)。这些报告的结果和结论不适用于原发性脾淋巴瘤的患者。作者从1584例霍奇金淋巴瘤中,鉴定出9例(0.57%)仅局限于脾脏(Ⅰ期)或脾门淋巴结(Ⅱ期)的患者。9例中。详细的临床检查未发现淋巴结肿大和肝肿大,但均有脾肿大。实验室检查包括血液、生化、SMA-16(包括胆红素、碱性磷酸酶、SGOT、SG-PT 和LDH)等指标;6例做了腹部淋巴管造影术(皆正常);多数进行了腹部超声、CT、和/或同位素扫描。所有患者均行剖腹术,7例施行了肝活检,5例进行了多处脾外腹部淋巴结活检。8例进行了骨髓活检。结果:最常见的症状是左上腹痛(67%)。脾肿大和血细胞减少的程度之间无相关性,白细胞分类计数血片观察正常。生化指标大部分无明显异常。非介入性放射学检查证实患者均有脾肿大,但无其他阳性发现。无一例有活检证明的脾外病变。经脾切除术
There have been many reports of splenic lymphoma, but many advanced diseases have been included (with concurrent hepatic lymphoma infiltration and / or extensive abdominal lymph node involvement). The results and conclusions of these reports do not apply to patients with primary splenic lymphoma. From 1584 Hodgkin’s lymphoma patients, 9 patients (0.57%) were identified as confined to spleen (stage I) or splenic lymph nodes (stage II). In 9 cases. Detailed clinical examination did not find swollen lymph nodes and hepatomegaly, but have splenomegaly. Laboratory tests included blood and biochemical markers such as SMA-16 (including bilirubin, alkaline phosphatase, SGOT, SG-PT, and LDH); 6 performed abdominal lymphangiography (all normal); most performed Abdominal ultrasound, CT, and / or isotope scans. All patients underwent laparotomy, liver biopsy performed in 7 patients, and multiple abdominal lymph node biopsy in 5 patients. Eight patients underwent bone marrow biopsy. Results: The most common symptom was left upper quadrant pain (67%). Splenomegaly and no correlation between the degree of cytopenia, white blood cell count was observed normal blood count. Most biochemical indicators no significant abnormalities. Non-interventional radiological examination confirmed that patients had splenomegaly, but no other positive findings. No case of biopsy proved spleen lesions. After splenectomy