论文部分内容阅读
法国波里尼西亚的塔哈岛为班氏丝虫病重度流行区。40岁以上的人口中16％为微丝蚴携带者。在1994年和1995年对该岛3岁以上的居民(孕妇除外)各进行一次服药治疗。该岛分为4个行政区,各区分别用不同剂量伊维菌素(IVM)和海群生(DEC)配伍治疗:1)IVM 400μg/kg加DEC 6mg/kg;2)单用IVM 400μg/kg;3)单用DEC 6mg/kg;4)IVM 400μg/kg加DEC 3mg/kg。服药后观察副作用数天。治疗前采20岁以上居民的静脉血,用膜过滤法检测有无微丝蚴,治疗效果的评估采用微丝蚴阳性率和几何均数密度。结果用X~2和Student′s检验法进行统计分析。
Taha Island in French Polynesia is a severe endemic area of Bancroftian filariasis. 16% of people over the age of 40 are carriers of microfilariae. In 1994 and 1995, residents over the age of 3 on the island (except pregnant women) were given medication each. The island is divided into four administrative regions, each area is treated with different doses of ivermectin (IVM) and seaquot (DEC): 1) IVM 400μg / kg plus DEC 6mg / kg; 2) IVM 400μg / kg alone; 3) DEC 6 mg / kg alone; 4) IVM 400 μg / kg plus DEC 3 mg / kg. Side effects observed after taking a few days. Venous blood from residents over the age of 20 was collected before treatment, and microfilariae were examined by membrane filtration. The therapeutic effect was evaluated using the positive rate of microfilariae and the geometric mean density. The results were analyzed statistically using X ~ 2 and Student’s test.