小儿乙型肝炎血清、病理及免疫病理分析

• 作 者: 鄢璞 苏燕莉 陈光华 张美德 黄炜 曾荣新 郑秀霞 赵西平 郝连杰
• 机 构: 广州市儿童医院，同济医科大学附属同济医院临床免疫室
• 出 处: 临床肝胆病杂志
• 发表日期: 1996年01期
• 关键词: 免疫病理 乙型肝炎 全部阳性 阳性病例 感染指标 复制状态 临床判断 肝细胞坏死 异株 小儿病

本文通过检测１５例小儿病毒性肝炎患者血清ＨＡＶ、ＨＢＶ、ＨＣＶ标志及肝组织内ＨＢｓＡｇ、ＨＢｃＡｇ发现ＨＡＶ和ＨＣＶ标志全部阴性，ＨＢＶ标志全部阳性，１５例ＨＢＶ感染中，血清ＨＢＶＤＮＡ阳性１１例。其中ＨＢｓＡｇ（＋）、ＨＢｅＡｇ（＋）ｇ例，ＨＢｓＡｇ（＋）、ＨＢｓＡｂ（＋）２例。综合血清其它的感染指标与肝脏病理及免疫病理的变化对１１例血清ＨＢＶＤＮＡ阳性病例作了重点分析。进一步证实ＨＢｅｇ为临床判断ＨＢＶ复制的良好指标，并推测本组两例ＨＢｅＡｂ（＋）、ＨＢＶＤＮＡ（＋）病例由前Ｃ变异株所致。

In this paper, HAV, HBV, HCV markers and HBsAg and HBcAg in liver tissue were detected in 15 cases of pediatric viral hepatitis. All the HAV and HCV markers were negative, and all the HBV markers were positive. Of the 15 cases of HBV infection, 11 cases were positive for HBVDNA. Including HBsAg (+), HBeAg (+) g cases, HBsAg (+), HBsAb (+) 2 cases. Serum HBVDNA positive cases were analyzed emphatically in 11 cases of other serological indicators of infection and changes of liver pathology and immunopathology. Further confirmed that HBeg is a good indicator of HBV replication in clinical judgment, and speculated that the two cases of HBeAb (+), HBVDNA (+) cases caused by the former C mutant.