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为了解女性尿毒症及肾移植受者性激素状态,作者应用酶联免疫法检测了50例女性患者肾移植前、后的性激素水平,并以15例近龄健康妇女对照。结果显示肾移植受者的泌乳素(PRL)、促卵泡素(FSH)及促黄体素(LH)较慢性肾功能衰竭(CRF)血液透析组明显降低,而雌二醇(E)和孕酮(P)值在正常范围。对于CRF患者检测发现PRL明显升高,而孕酮值显著下降,经给该组闭经患者作克罗米酚刺激试验,结果阳性,说明闭经为下丘脑性功能障碍。作者认为成功肾移植可纠正肾衰患者由于血中肌酐、尿素氮升高造成的下丘脑功能障碍,且能恢复正常月经周期及生育力。透析期间可对症治疗,但不必促排卵,而成功肾移植是最好的治疗方法。
To understand the female uremic and renal transplant recipients of sex hormone status, the authors used enzyme-linked immunosorbent assay 50 cases of female patients before and after kidney transplantation, the level of sex hormones, and 15 cases of healthy women controls. The results showed that PRL, FSH and LH in CRF hemodialysis group were significantly lower than those in CRF group, but estradiol (E) and progesterone (P) ) Value in the normal range. For patients with CRF found PRL significantly increased, while the progesterone value decreased significantly, given to the group of patients with amenorrhea clomiphene stimulation test, the results showed that amenorrhea for hypothalamic sexual dysfunction. The authors believe that successful kidney transplantation can correct hypothalamic dysfunction caused by elevated blood creatinine and urea nitrogen, and can restore normal menstrual cycle and fertility. During dialysis symptomatic treatment, but do not have to promote ovulation, and successful kidney transplantation is the best treatment.