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检测４０例２０～４０岁Ⅰ期原发性高血压患者尿徽量白蛋白排泄率Ｕｒｉｎａｃｙａｌｂｕｍｉｎｅｘｃｒｅｔｉｏｎ（ＵＡＥ）和选择性蛋白尿指数ＳｅｌｅｃｔｉｖｅＰｒｏｔｅｉｎｕｒｉａｉｎｄｅｘ（ＳＰＩ）。将患者年龄、病程和血压与ＵＡＥ、ＳＰＩ作相关分析。结果发现：高血压患者和正常人相比，ＵＡＥ增加、ＳＰＩ下降（Ｐ＜０．０５）；高血压病组ＵＡＥ与血压呈正相关（Ｐ＜０．０５），与年龄和病程无相关性；用硝苯碇、阿替洛尔治疗２周后ＵＡＥ无明显变化，而用卡托普利治疗２周后ＵＡＥ下降（Ｐ＜０．０５），但其降血压幅度与ＵＡＥ下降幅度之间无相关性。以上结果表明：（１）Ⅰ型原发性高血压患者肾小球毛细血管壁对大分子蛋白质的通透性不如中分子蛋白质显著，结构受损尚轻微；（２）不同种类的降压药引起全身血压同等程度下降时，对肾小球血流动力学的作用并不一致。
Urinacyalbuminexcretion (UAE) and selective proteinuria index (SPI) were measured in 40 patients with stage I essential hypertension with 20-40 years of age. Patient age, duration of disease and blood pressure and UAE, SPI for the correlation analysis. The results showed that UAE increased and SPI decreased (P <0.05) in hypertensive patients compared with normal subjects. There was a positive correlation between UAE and blood pressure in hypertensive patients (P <0.05), but no correlation with age and course of disease. After treated with nifedipine and atenolol for 2 weeks, there was no significant change in UAE, but UAE decreased after 2 weeks of treatment with captopril (P <0.05), but there was no significant difference between the reduction of blood pressure and the decrease of UAE Correlation. The above results indicate that: (1) The permeability of glomerular capillary wall to macromolecular protein in patients with type I essential hypertension is not as good as that of middle molecular protein, and the structural damage is still slight; (2) Different types of antihypertensive drugs Caused by the same decline in systemic blood pressure, the role of glomerular hemodynamics is not consistent.