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目的探讨雄激素受体(AR)在国人雄激素非依赖性前列腺癌(AIPC)的表达及其临床意义。方法采用免疫组化两步法,检测AR在15例AIPC和20例雄激素依赖性前列腺癌(ADPC)组织标本的表达水平。结果1例AIPC无AR表达,其余14例AIPC及全部ADPC均有AR高表达,AIPC染色的光密值为0.31±0.04较ADPC0.28±0.03升高。结论大多数国人AIPC均高表达AR,AR的异常表达可能在前列腺癌的进展中发挥重要的作用。
Objective To investigate the expression of androgen receptor (AR) in androgen-independent prostate cancer (AIPC) in Chinese and its clinical significance. Methods Immunohistochemistry was used to detect the expression of AR in 15 cases of AIPC and 20 cases of androgen-dependent prostate cancer (ADPC). Results One case of AIPC had no AR expression. The other 14 cases of AIPC and all of ADPC had high AR expression. The AIPC stained light density was 0.31 ± 0.04 higher than that of ADPC 0.28 ± 0.03. Conclusion Most Chinese people with AIPC express AR highly. Abnormal expression of AR may play an important role in the progression of prostate cancer.