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近年来呼吸生理和肺部疾病研究中对肺表面活性物质颇为重视,其注意力大多集中在肺表面活性物质对维持肺泡的正常稳定的作用上,比较注重研究肺表面活性物质在成人呼吸窘迫综合征、新生儿透明膜肺以及肺不张等疾病的发病机理中的作用,而对肺表面活性物质与小气道功能之间的关系则较少涉及。现结合国内外有关文献,拟就这方面问题进行初步探讨,以期更全面地探讨影响小气道阻力的各种因素。Picken等于1972年报告了一组上呼吸道病毒感染患者在感染期及恢复期肺动态顺应
In recent years, respiratory physiology and lung disease research has paid much attention to pulmonary surfactant, and its attention is mostly focused on the role of pulmonary surfactant in the maintenance of normal and stable alveolar function. More attention is paid to the study of pulmonary surfactant in adult respiratory distress Syndrome, neonatal hyaline membrane lung and atelectasis and other diseases in the pathogenesis of the role, but the relationship between pulmonary surfactant and small airway function is less involved. Based on the relevant literature both at home and abroad, we are going to conduct preliminary discussions on this issue in order to explore more fully the various factors that affect the resistance of small airways. Picken et al. Reported in 1972 that a group of patients with upper respiratory tract infection had dynamic pulmonary compliance during infection and recovery