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  5. GADD45α参与维持基因组稳定性并发挥肿瘤抑制效应的多样性分子机制

GADD45α参与维持基因组稳定性并发挥肿瘤抑制效应的多样性分子机制

来源 :生物技术通讯 | 被引量 : 0次 | 上传用户：housekingzuo
【摘 要】
：
哺乳动物细胞在遣受应激损伤因素刺激时会启动一系列信号传导通路,从而引发细胞周期阻滞、DNA修复或细胞凋亡等效应,这些机制的异常与肿瘤的发生发展密切相关.GADD45α作为生
【作 者】
：
郝一 
【机 构】
：
军事医学科学院,兰州大学
【出 处】
：
生物技术通讯
【发表日期】
：
2004年期
【关键词】
：
GADD45α 基因组稳定性 肿瘤 
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论文部分内容阅读
哺乳动物细胞在遣受应激损伤因素刺激时会启动一系列信号传导通路,从而引发细胞周期阻滞、DNA修复或细胞凋亡等效应,这些机制的异常与肿瘤的发生发展密切相关.GADD45α作为生长阻滞及DNA损伤诱导基因编码家族的一员,参与维持基因组稳定性、调控细胞周期行进、DNA损伤修复、细胞衰老及细胞凋亡等多种生物学过程,在肿瘤发生发展和肿瘤抑制反应中具有重要作用.我们简要综述了GADD45α参与维持基因组稳定性并发挥肿瘤抑制效应的分子机制.
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