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目的:探究在初发性2型糖尿病临床治疗中,磷酸西格列汀与二甲双胍的应用效果。方法:选取我院2012年3月~2014年6月内分泌科收治的初发性2型糖尿病患者150例,并将其随机分为对照组与研究组。均给予两组常规治疗方法。在此基础上,给予研究组口服磷酸西格列汀片和二甲双胍片。观察两组患者的空腹血糖、糖化血红蛋白、餐后两小时血糖、空腹胰岛素、胰岛素抵抗指数。结果:在治疗后,与对照组相比,研究组患者的空腹血糖、餐后两小时血糖、胰岛素抵抗指数、空腹胰岛素明显较优。两组比较,差异具有统计学价值(p<0.05)。结论:在初发性2型糖尿病的临床治疗中,磷酸西格列汀与二甲双胍的联合能够实现良好的治疗效果,且安全性较高,值得推广应用。
Objective: To investigate the clinical effect of sitagliptin phosphate and metformin in the treatment of type 2 diabetes mellitus. Methods: A total of 150 patients with newly diagnosed type 2 diabetes admitted to Department of Endocrinology from March 2012 to June 2014 in our hospital were selected and randomly divided into control group and study group. Two groups were given conventional treatment. On this basis, the study group was given oral sitagliptin phosphate tablets and metformin tablets. Fasting blood glucose, glycosylated hemoglobin, two-hour postprandial blood glucose, fasting insulin and insulin resistance index were observed in two groups. Results: After treatment, the fasting blood glucose, the two-hour postprandial blood glucose, insulin resistance index and fasting insulin in the study group were significantly better than those in the control group. The differences between the two groups were statistically significant (p <0.05). Conclusions: The combination of sitagliptin phosphate and metformin in clinical treatment of newly diagnosed type 2 diabetes can achieve good therapeutic effect and high safety, which is worth popularizing and applying.