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目的采用固体分散技术,提高冬凌草甲素的体外溶解性能。方法分别以聚乙二醇6000(PEG6000)、聚乙烯吡咯烷酮K30(PVPK30)为载体,制备冬凌草甲素固体分散体。采用紫外分光光度法进行含量测定,差示热分析法鉴别药物在载体中的存在状态,并进行溶解度、体外溶出速率实验。结果两种载体的固体分散体均能增加药物的溶解度和溶出速率,冬凌草甲素在载体中以高度分散状态存在。结论以PVPK30为载体制备的冬凌草甲素固体分散体体外溶解度和溶出速率明显提高。
Objective To improve the in vitro solubility of oridonin by using solid dispersion technology. Methods The oridonin solid dispersions were prepared with polyethylene glycol 6000 (PEG6000) and polyvinylpyrrolidone K30 (PVPK30) as carriers respectively. UV spectrophotometry was used to determine the content, differential thermal analysis to identify the presence of drugs in the carrier, and solubility, in vitro dissolution rate experiments. Results Both solid dispersions of the carriers increased the drug’s solubility and dissolution rate and the oridonin was present in a highly dispersed state in the carrier. Conclusion The solubility and dissolution rate of oridonin solid dispersions prepared with PVPK30 as carrier were significantly increased.