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由L—半胱氨酸与2—吡啶甲醛缩合制备了手性配体2—(2—吡啶基)—4—羧基—1,3—噻唑烷,并将其与〔Rh(COD)Cl〕2制备的在位催化剂用于苯乙酮的催化不对称硅氢化反应,可使该反应的化学产率高达90%,光学收率达到797%e.e.
The chiral ligand 2- (2-pyridyl) -4-carboxy-1,3-thiazolidine was prepared by the condensation of L-cysteine with 2-pyridinecarboxaldehyde and reacted with [Rh 2 prepared in-situ catalyst for acetophenone catalytic asymmetric hydrosilation reaction, the chemical yield of the reaction up to 90%, the optical yield of 79 7% e. e.