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小儿实体恶性肿瘤化疗失败的主要原因之一是肿瘤细胞对抗癌药物的耐受。肿瘤细胞的耐药性可分为内在耐药性（Intrinsicdrugsistance）及获得性耐药性（Acquiteddrugresistance）两种。内在耐药与反复接触致癌剂所致基因突变有关，在化疗前就存在。获得性耐药在化疗过程中肿瘤细
One of the major causes of failure of chemotherapy in pediatric solid tumors is the tolerance of tumor cells to anticancer drugs. Tumor cell resistance can be divided into intrinsic resistance (Intrinsicdrugsistance) and acquired drug resistance (Acquiteddrugresistance) two. Intrinsic resistance and repeated exposure to carcinogens caused by mutations in the gene exist before chemotherapy. Acquired drug resistance in the course of chemotherapy thin