远隔器官缺血预处理心脏保护作用的研究进展

• 作 者: 李春梅 张兴华
• 机 构: 山东大学山东省立医院心内科,山东大学山东省立医院心内科 山东济南250021,山东济南250021
• 出 处: 心血管病学进展
• 发表日期: 2006年05期
• 关键词: 远隔预处理 缺血预处理 心脏保护

心肌缺血预处理现象的发现,为心肌缺血再灌注损伤的预防开拓了一个新的研究领域。近年来,随着预处理研究的不断深入,其方法学也有一些新的进展。研究发现,心外组织如肾脏、小肠及骨骼肌短暂缺血不仅能减轻局部组织的再灌注损伤,对远隔的心脏也有保护作用,并将这种现象称为远隔预处理。现就远隔器官缺血预处理对心脏的保护作用及其机制作一简要综述。

The discovery of myocardial ischemic preconditioning opens up a new field of research for the prevention of myocardial ischemia-reperfusion injury. In recent years, with the deepening of the research on pretreatment, there have been some new developments in its methodology. The study found that epicardial tissue such as kidney, small intestine and skeletal muscle transient ischemia can not only reduce the local tissue reperfusion injury, also have a protective effect on the distant heart, and this phenomenon is called remote preconditioning. Now on the remote organ ischemic preconditioning on the heart of the protective effect and its mechanism made a brief review.