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目的:研究金樱根、茎不同炮制品的抗菌、急性抗炎及慢性抗炎作用,为其药材质量标准及其炮制品的临床使用提供依据。方法:金樱根、茎生品与炮制所得醋炙品、盐炙品、黑豆汁炙品及蜜炙品共10种样品水提取物,观察其对枯草芽孢杆菌、金黄色葡萄球菌等10种菌的抗菌作用;用二甲苯致小鼠耳廓肿胀试验研究急性抗炎能力;用小鼠棉球肉芽肿试验观察慢性抗炎作用。结果:金樱根炮制品的抑菌作用强于茎炮制品,尤其是金樱根蜜炙品抑菌作用明显;所有炮制品对二甲苯引起小鼠耳廓肿胀均无抑制作用;金樱根生品、茎盐炙品、茎蜜炙品和根蜜炙品对小鼠棉球肉芽肿的生成具有显著抑制作用。结论:金樱根蜜炙品有明显的抑菌作用和对小鼠慢性炎症的抗炎作用。
OBJECTIVE: To study the antibacterial, acute anti-inflammatory and chronic anti-inflammatory effects of different processed products from the roots and stems of Jin Ying and to provide the basis for the quality standard of the medicinal materials and the clinical use of the processed products. Methods: A total of 10 kinds of water extract from the roots, stems and the processed vinegar, sunburn, black bean juice and honey Sunburn were collected and observed for 10 kinds of bacteria, such as Bacillus subtilis and Staphylococcus aureus Antibacterial effect; Xylene-induced mouse ear auricle swelling test to study the acute anti-inflammatory ability; Using mouse cotton ball granuloma test to observe chronic anti-inflammatory effect. Results: The antibacterial effect of Jin Ying root products was stronger than that of stem products. Especially, the antibacterial effect of Jin Ying root honey dew was obvious. All the processed products had no inhibitory effect on the ear swelling caused by xylene. Product, stem honey Minamata and honey Minamata products have a significant inhibitory effect on the formation of cotton ball granuloma in mice. Conclusion: Jin Ying root honey Sunburn products have obvious bacteriostasis and anti-inflammatory effects on chronic inflammation in mice.