论文部分内容阅读
目的：比较舍曲林和氯丙咪嗪治疗强迫症的疗效和不良反应。方法：用ＣＣＭＤ２Ｒ和ＤＳＭⅣ作为诊断标准，用ＹａｌｅＢｒｏｗｎ强迫量表，ＮＩＭＨ强迫量表，ＨＡＭＤ，ＨＡＭＡ和ＴＥＳＳ量表评定临床疗效和不良反应，对４９例强迫症患者进行随机双盲的８周治疗。结果：舍曲林有效率为８４％，与氯丙咪嗪７９．１７％相近，两者无显著差异（χ２＝０．１９，Ｐ＞０．０５）。舍曲林不良反应发生率４４％，明显少于氯丙咪嗪８３．３３％。两者有明显差异（χ２＝８．１５，Ｐ＜０．０１）。结论：舍曲林治疗强迫症，疗效与氯丙咪嗪相当，不良反应较轻，耐受性好。
Objective: To compare the efficacy and side effects of sertraline and clomipramine in the treatment of obsessive-compulsive disorder. Methods: Using CCMD2R and DSMⅣ as diagnostic criteria, the clinical efficacy and adverse reactions were assessed by YaleBrown Oblige Scale, NIMH Enforcement Scale, HAMD, HAMA and TESS Scale, and 49 obsessive-compulsive disorder patients Randomized double-blind treatment for 8 weeks. Results: The effective rate of sertraline was 84%, similar to that of clomipramine 79.17%. There was no significant difference between the two (χ2 = 0.19, P> 0.05). The incidence of sertraline adverse reactions was 44%, significantly less than clomipramine 83.33%. There was a significant difference between the two (χ2 = 8.15, P <0.01). Conclusion: Sertraline treatment of obsessive-compulsive disorder, efficacy and clomipramine equivalent, mild adverse reactions, well tolerated.