论文部分内容阅读
为探讨肝泡型包虫病 (Alveolar echinococcosis AE)临床分期与 s IL- 2 R,TNF- α和 IFN- γ含量的关系和意义 ,将经B超和血清学方法证实的 2 3例 AE病人和对照组 1 2人采血后 ,用 ELISA双抗体夹心法 ,做 s IL- 2 R,TNF-α和 IFN-γ含量的测定。按 B超肝脏扫描的声像损害情况 ,将 AE分期 (组 ) ,对照相应细胞因子的含量 ,经方差分析和 Q检验 ,讨论细胞因子在 AE发育增殖中的可能作用和临床意义。结果 P2 组、P3 组、P4组和对照组 s IL- 2 R每 m L含量均值分别为 96.57u、2 2 6.44u、1 93.81 u、1 1 0 .89u;TNF- α含量均值分别为 P2 组 1 .1 2 μg/ L,P3 组 3.67μg/ L,P4组 1 .30 μg/ L,对照组则为 0 .40μg/ L;IFN-γ含量均值分别为 P2 组 360 ng/ L,P3 组 486 ng/ L,P4组 2 59ng/ L,对照组则为 1 5.63 ng/ L;各组经方差分析和 Q检验 ,证实 AE病人病理的三个不同时期 ,其 s IL- 2 R,TNF- α和 IFN- γ的含量均有显著性差异 (P<0 .0 1 )。 s IL- 2 R含量均值除 P2 与对照组无差异外 (P>0 .0 5) ,其余各组与 P2 组和对照组均有显著性差异 (P<0 .0 5) ;TNF- α含量在 P3 组最高 (P<0 .0 1 ) ;AE各组病人的 IFN- γ含量明显高于对照组 (P<0 .0 1 ) ,而 AE病人组间却并无差异 (P>0 .0 5)。低水平的 s IL-
In order to investigate the relationship between the clinical stage of Alveolar echinococcosis and the levels of IL-2R, TNF-α and IFN-γ, 23 AE patients confirmed by B-ultrasonography and serological methods And control group of 12 people after blood collection, ELISA double antibody sandwich method, determination of s IL-2 R, TNF-α and IFN-γ content. According to the ultrasonographic damage of B-liver scan, the possible role and clinical significance of the cytokines in the development of AE were discussed by the AE staging (group) and the corresponding cytokine content by variance analysis and Q test. Results The mean levels of IL-2R per mL in P2, P3, P4 and control groups were 96.57u, 22.44u, 1 93.81u, 11.08u, respectively. The mean TNF-α contents were P2 Group 1.12 μg / L, P3 group 3.67 μg / L, P4 group 1.30 μg / L, while the control group was 0.40 μg / L; IFN-γ content were P2 group 360 ng / L, P3 Group 486 ng / L, group P4 59 ng / L, while control group was 1 5.63 ng / L; each group by ANOVA and Q test to confirm the AE pathology in three different periods, the s IL-2 R, TNF - α and IFN - γ contents were significantly different (P <0.01). The levels of IL-2R were significantly higher than those of P2 and control (P <0.05) except P2 and control group (P> 0.05) The content of IFN-γ in group AE was significantly higher than that in control group (P <0.01), but there was no difference between group AE and group AE (P> 0 01) .0 5). Low levels of IL-