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前瞻性观察１６例肾功能正常患者造影前、造影后２４，４８ｈ肾功能动态变化。造影后２４ｈ血尿素氮（ＢＵＮ）、血清肌酐（ＳＣｒ）无显著变化（Ｐ＞０．０５）、尿谷氨酰转肽酶（γ－ＧＴ）、Ｎ－乙酰基－β－Ｄ氨基葡萄糖苷酶（ＮＡＧ）、乳酸脱氢酶（ＬＤＨ）较造影前显著增高（Ｐ＜０．０１）。造影后４８ｈＢＵＮ，ＳＣｒ显著增高（Ｐ＜０．０ｌ），尿γ－ＧＴ，ＮＡＧ，ＬＤＨ显著恢复（Ｐ＜０．０５）；但仍明显高于造影前，差异有显著性（分别Ｐ＜０．０１，０．０１，０．０５）。提示在肾功能正常患者泛影葡胺对肾小管损害呈一过性，尿γ－ＧＴ是评估碘造影剂肾毒性亚临床期敏感指标
Prospective observation of 16 patients with normal renal function before angiography, 24,48 h after renal function dynamic changes. Blood urea nitrogen (BUN), serum creatinine (SCr) had no significant change at 24h after angiography (P> 0.05), urinary glutamyl transpeptidase (γ-GT), N-acetyl-β-D glucosaminide Enzyme (NAG), lactate dehydrogenase (LDH) were significantly higher than before angiography (P <0.01). After 48h, the levels of BUN and SCr were significantly increased (P <0.01), and the urinary γ-GT, NAG and LDH were significantly recovered (P <0.05), but still significantly higher than those before angiography .01, 0.01, 0.05). Prompted in patients with normal renal function diatrizoate meglumine on tubule damage was transient, urine γ-GT is to assess iodine contrast agent nephrotoxicity subclinical sensitive index