The journey of multifunctional bone scaffolds fabricated from traditional toward modern techniques

• 作 者: Ashkan Bigham Firoozeh Foroughi Erfan Rezvani Ghomi Mohammad Rafienia Rasoul Esmaeely Neisiany Seeram Ramakrishna
• 机 构: Department of Biomaterials, Tissue Engineeringand Nanotechnology, School of Advanced Technologies in
• 出 处: 生物设计与制造（英文版）
• 发表日期: 2020年4期
• 关键词: Multifunctional scaffolds Bone cancer Fabrication techniques Bone tissue regener

As a bone scaffold, meeting all basic requirements besides dealing with other bone-related issues—bone cancer and acceler-ated regeneration—is not expected from traditional scaffolds, but a newer class of scaffolds called multifunctional. From a clinical point of view, being a multifunctional scaffold means reducing in healing time, direct costs—medicine, surgery, and hospitalization—and indirect costs—loss of mobility, losing job, and pain. The main aim of the present review is follow-ing the multifunctional bone scaffolds trend to deal with both bone regeneration and cancer therapy. Special consideration is given to different fabrication techniques which have been applied to yield these materials spanning from traditional to mod ones. Moreover, the hierarchical structure of bone plus bone cancers and available medicines to them are introduced to familiarize the potential reader of review with the pluri-disciplinary essence of the field. Eventually, a brief discussion relating to the future trend of these materials is provided.