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目的 :探讨血清胆红素浓度与急性动脉硬化性脑梗死的关系。方法 :测定 2 16例急性脑梗死患者血清胆红素浓度 (分为脑梗组 13 4例 ,腔梗组 82例 ) ,98例健康体检者和 84例其它疾病组作对照。结果 :脑梗组间接胆红素显著低于对照组、其它疾病组 ( t=6.43 8,t=6.5 17,P <0 .0 0 1) ,也显著低于腔梗组 ( t=2 .741,P <0 .0 1) ;腔梗组间接胆红素显著低于对照组和其它疾病组 ( t=2 .782 ,t=2 .774,P均 <0 .0 1) ,直接胆红素四组间无显著差异。脑梗死灶容积与间接胆红素水平呈负相关 ,差异有非常显著性 ( r =-0 .73 9,t=14 .2 7,P <0 .0 1)。结论 :提示低血清胆红素可作为动脉硬化性脑梗死的独立危险因素。这对研究脑梗死的发病机理及预防均有一定的价值
Objective: To investigate the relationship between serum bilirubin concentration and acute arteriosclerotic cerebral infarction. Methods: Serum bilirubin concentrations were measured in 2 16 patients with acute cerebral infarction (divided into 134 cases in cerebral infarction group and 82 in luminal infarction group), 98 cases of healthy subjects and 84 cases of other disease groups. Results: Indirect bilirubin in cerebral infarction group was significantly lower than that in control group. Other disease groups (t = 6.43 8, t = 6.517, P <0.01) were also significantly lower than those in control group (t = 2. 741, P <0.01). Indirect bilirubin in the lumen group was significantly lower than that in the control group and other disease groups (t = 2.782, t = 2.774, P <0.01) There was no significant difference between the four groups. The volume of cerebral infarction was negatively correlated with the level of indirect bilirubin, the difference was significant (r = -0.73 9, t = 14.27, P <0.01). Conclusion: It suggests that low serum bilirubin may be an independent risk factor for atherosclerosis cerebral infarction. This study of the pathogenesis and prevention of cerebral infarction have a certain value