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由感染日本血吸虫兔肝取新鲜纯卵,在体外用0.01～100μg/ml浓度的吡喹酮于4℃处理30～120min后,于无药清水中进行毛蚴孵化试验,结果表明:(1)毛蚴孵化,0.01μg/ml处理30～120min的虫卵不被抑制,0.1μg/ml处理120min和1μg/ml处理30min的虫卵显部分抑制,而10μg/ml处理60min和100μg/ml处理30min的虫卵呈完全抑制;(2)沉渣镜检,孵化未被抑制和未被完全抑制的各药物处理组及对照组,其孵化后的空壳率明显增多;而孵化被完全抑制的各药物处理组的空壳率在孵化前后无显著差别。说明吡喹酮对虫卵毛蚴孵化有直接的抑制作用。
The fresh pure eggs from rabbits infected with Schistosoma japonicum were in vitro treated with praziquantel at a concentration of 0.01-100 μg / ml for 30-120 min at 4 ° C. The results showed that: (1) The hatching, the eggs of 0.01μg / ml for 30 ~ 120min were not inhibited, the eggs of 0.1μg / ml for 120min and 1μg / ml for 30min were partially inhibited, while 10μg / ml for 60min and 100μg / ml for 30min Eggs completely inhibited; (2) sediment microscopy, incubation was not inhibited and not completely inhibited each drug treatment group and the control group, the hatched shell percentage increased significantly; hatching is completely inhibited each drug treatment group No significant difference in shell rate before and after hatching. Praziquantel shows that egg epicarcoma hatching has a direct inhibitory effect.