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作者就蛋白的摄取量对上尿路结石,特别是与含钙结石生成相关物质的影响及机理用动物实验和临床病例进行了研究探讨。动物实验系用10周龄Vistaz纯系雄性大白鼠,分3组,分别给高、中、低蛋白含量的食物4周后,对尿中钙、环—磷酸腺苷(cAMP)、枸橼酸、草酸、尿PH值等与生成结石有关的物质及血PH值进行了测定。结果发现高蛋白食物组的尿中钙排泄量明显增加,枸橼酸排泄量明显减少,同时出现代谢性酸血症,尿中cAMP排泄量增加以及股骨骨盐量减少。作者认为尿中钙排泄量增加的机理是由于持续过多地摄取蛋白质,特别是动物性蛋白质,引起体内慢性酸中毒而导致钙从肾脏排泄量的持续增多,产生负钙平
The author of protein intake on the upper urinary tract stones, especially calcium-related stones and the formation of substances related to the impact of animal experiments and clinical cases were studied. The animal experiments were conducted in 10-week-old male Vistaz male rats in three groups, respectively, high, medium and low protein content of food for 4 weeks after the urinary calcium, cAMP, citrate , Oxalic acid, urine PH value and the formation of stones-related substances and blood PH values were determined. The results showed that high protein diet group significantly increased urinary calcium excretion, citrate excretion was significantly reduced, accompanied by metabolic acidosis, increased urinary cAMP excretion and decreased bone mineral salt. The author believes that the mechanism of increased urinary calcium excretion is due to continued excessive intake of protein, especially animal protein, causing chronic acidosis in the body resulting in a continuous increase in calcium excretion from the kidneys, resulting in negative calcium levels